Patients with Alzheimer’s
disease generally remain warm and engaged despite their cognitive decline, but
those with the behavioural-variant of frontotemporal dementia (bvFTD) undergo a
jarring change in personality.
These early-onset
dementia patients have blunted emotions and become puzzled by affection,
uninterested in socialising and less responsive to the feelings of others.
But a study published in
the Journal of Alzheimer’s Disease may give comfort to carers who have
borne the brunt of these changes. It indicates that the changes result
from fading grey matter in the region of the brain that governs empathy.
Researchers from
Neuroscience Research Australia investigated 71 individuals including 25 with
Alzheimer’s, 24 with bvFTD and 22 healthy older control participants through
cognitive assessments, carer interviews and neuroimaging.
Both the experimental
groups had reduced capacity to understand and appreciate the emotions of
others, known as cognitive empathy. But the bvFTD patients were
significantly more impaired when it came to sharing the emotions and emotional
experiences of others – or affective empathy.
The impairment in cognitive
empathy among the Alzheimer’s group was found to be a consequence of their
overall cognitive decline, rather than an impairment in empathy per se.
So while they found it
difficult to explain how a book character might be feeling, they were still
likely to become upset if they saw somebody crying in the street.
But among the bvFTD
patients, the loss of empathy was related to patchy grey matter in the
frontoinsular cortices of the brain, the integrity of which is critical to
social functioning.
Lead author Muireann
Irish said this explained why Alzheimer’s patients continued to be socially
appropriate in spite of the decline in cognitive function. “There isn’t the
change in personality, which I think is one of the most jarring things about
frontotemporal dementia patients,” Dr Irish said. “(This study) gives more
knowledge and insight to the caregivers that there’s an organic reason for this
change that becomes so distressing.” “Empathy is an abstract concept in a way.
It's not as easily quantified as memory loss or changes in language and it can
be seen as a personality issue or somebody being deliberately unsympathetic,
but this shows there’s a region in the brain that changes.”
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